Fluctuating levels of cholesterol and triglycerides linked to increased
risk of dementia

Date:
July 5, 2023
Source:
American Academy of Neurology
Summary:
Older people who have fluctuating levels of cholesterol and
triglycerides may have a higher risk of Alzheimer's disease and
related dementias compared to people who have steady levels,
according to new research.

While the study found a link, it does not prove that fluctuating
levels of cholesterol and triglycerides cause dementia.


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FULL STORY ========================================================================== Older people who have fluctuating levels of cholesterol and triglycerides
may have a higher risk of Alzheimer's disease and related dementias
compared to people who have steady levels, according to new research
published in the July 5, 2023, online issue of Neurology(R), the medical journal of the American Academy of Neurology. While the study found
a link, it does not prove that fluctuating levels of cholesterol and triglycerides cause dementia.

"Prevention strategies for Alzheimer's and related dementias are
urgently needed," said study author Suzette J. Bielinski, PhD, of the
Mayo Clinic in Rochester, Minnesota. "Routine screenings for cholesterol
and triglyceride levels are commonly done as part of standard medical
care. Fluctuations in these results over time could potentially help
us identify who is at greater risk for dementia, help us understand
mechanisms for the development of dementia and ultimately determine
whether leveling out these fluctuations could play a role in reducing
dementia risk." Researchers used health care data to identify 11,571
people age 60 or older who did not have a prior diagnosis of Alzheimer's disease or dementia. Researchers looked at participants' measurements of
total cholesterol, triglycerides, low- density lipoprotein cholesterol
(LDL) and high-density lipoprotein cholesterol (HDL) on at least three different days in the five years before the start of the study.

Then researchers divided participants into five equal groups based on
how much the measurements fluctuated. The lowest group had the least
variation over time and the highest group had the most variation.

Participants were followed for an average of 13 years. During that time,
2,473 people developed Alzheimer's disease or another form of dementia.

After adjusting for variables that could affect risk of dementia including
sex, race, education and lipid-lowering treatments, researchers found
for total cholesterol, participants in the highest group had a 19%
increased risk of dementia compared to those in the lowest group. Of the
2,311 people in the highest group, 515 developed dementia compared to
483 of the 2,311 people in the lowest group. For triglycerides, those
in highest group had a 23% increased risk.

Researchers did not find a link between variations in LDL and HDL and
an increased risk of dementia.

"It remains unclear why and how fluctuating levels of cholesterol
and triglycerides are related to the risk of Alzheimer's disease,"
said Bielinski.

"Further studies looking at the changes over time for this relationship
are needed in order to confirm our results and potentially consider preventative strategies." A limitation of the study was researchers
looked at Alzheimer's disease and related dementias as a whole and did
not differentiate between the types of dementia.

The study was supported by the National Heart, Lung and Blood Institute.

* RELATED_TOPICS
o Health_&_Medicine
# Cholesterol # Alzheimer's_Research # Triglycerides #
Healthy_Aging
o Mind_&_Brain
# Alzheimer's # Dementia # Disorders_and_Syndromes #
Caregiving
* RELATED_TERMS
o Cholesterol o Dementia_with_Lewy_bodies o
Low_density_lipoprotein o Facial_symmetry o Hypercholesterolemia
o Alzheimer's_disease o Excitotoxicity_and_cell_damage o
High_density_lipoprotein

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========================================================================== Journal Reference:
1. Ethan D. Moser, Sheila M. Manemann, Nicholas B. Larson, Jennifer
L. St.

Sauver, Paul Y. Takahashi, Michelle M. Mielke, Walter A. Rocca,
Janet E.

Olson, Ve'ronique L. Roger, Alan T. Remaley, Paul A. Decker, Jill M.

Killian, Suzette J. Bielinski. Association Between Fluctuations
in Blood Lipid Levels Over Time With Incident Alzheimer Disease
and Alzheimer Disease Related Dementias. Neurology, 2023; DOI:
10.1212/ WNL.0000000000207595 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2023/07/230705171104.htm

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